Source: http://news.feedzilla.com/en_us/stories/politics/top-stories/322054886?client_source=feed&format=rss
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With the casting of Rome alum Ciar?n Hinds as Mance Rayder in season three, Game of Thrones established that it has no problem getting talent from HBO?s long-deceased show about Rome?s transition from republic to empire.
Credit: Franco Biciocchi/HBO
Case in point: the series has cast Rome actress Indira Varma in season four. Varma will play Ellaria Sand on the show, the ?sexually adventurous paramour? of ?The Red Viper? Prince Oberyn Martell (to be played by Pedro Pascal).
In addition to her role as Niobe on Rome, Varma has had roles on FOX?s Human Target along with UK dramas Silk and Hunted.
Varma is the latest new addition to season 4 following new hires Pascal and Sherlock writer/actor Mark Gatiss. In the wake of the show?s highest-rated and most-Emmy-nominated season yet, Game of Thrones producers David Benioff and D.B. Weiss said they expect season 4 to be the show?s best.
?We got more action, which is obviously more time consuming,? says Benioff. ?It?s a brutal shooting season ahead. But if we can make it through, yeah, I think it?s going to surpass season three. The last 3 episodes, there?s so many scenes we?ve been waiting for so long to do. And it just gets more and more fun to write for these characters. After three years of doing it, we have that much more comfort to make everything uncomfortable for them. We?re very excited for it.?
Via: Entertainment Weekly
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Source: http://feeds.sciencedaily.com/~r/sciencedaily/strange_science/~3/ANecXEK9lNo/130724124919.htm
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The Justice Ministry is preparing a bill that will subject the Jewish National Fund-Keren Kayemet Le?yisrael to audit by the state comptroller, exposing it to external review for the first time in its long history.
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Baby mice exposed in the womb to low doses ? but not high doses ? of bisphenol A were fatter and had metabolic changes linked to obesity and diabetes, according to a new study
By Brian Bienkowski and Environmental Health News
Sleeping mouse. Image: Flickr/Eddy Van 3000
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Baby mice exposed in the womb to low doses ? but not high doses ? of bisphenol A were fatter and had metabolic changes linked to obesity and diabetes, according to a new study published Thursday.
Building on previous studies that link the hormone-altering chemical to changes in body weight and glucose tolerance, the new research fuels an ongoing controversy over whether federal testing of chemicals is adequate to protect people from low doses.
?What?s scary is that we found effects at levels that the government not only says is safe, but that they don?t bother to test,? said Fredrick vom Saal, a University of Missouri, Columbia, professor and senior author of the study published in the journal Reproductive Toxicology.
Many of the effects were reported in the mice fed daily doses ? just during pregnancy ? that were one-tenth of the amount that the U.S. Environmental Protection Agency says is safe for daily exposure throughout life.
Used in polycarbonate plastics, canned food liners and some thermal receipts, BPA is found in almost everyone?s body. Some earlier studies have linked it to obesity and diabetes in people.
Vom Saal said low doses of BPA caused a ?deranged metabolism? in the offspring of the exposed pregnant mice, suggesting that ?a component of the obesity epidemic and other metabolic diseases can be due to chemical exposure during development, when your cells are being programmed.?
In the offspring mice, BPA was associated with weight gain, increased abdominal fat and eating, impaired glucose tolerance and increased hormones that regulate glucose and appetite. Those outcomes, however, only happened when mothers were fed daily doses at or below 5,000 micrograms of BPA per kilogram of body weight. That amount is the EPA?s ?no effects? level ? the daily amount that the agency has concluded would not cause any human effects.
Of the doses fed to the pregnant mice ? 5, 50, 500, 5,000 and 50,000 micrograms per kilogram ? 500 caused the most metabolic changes, vom Saal said. The number of fat cells doubled at that dose. No effects were seen at doses higher than 5,000.
The study adds to the controversy over a phenomenon called ?nonmonotonic dose response,? which means that hormone-like chemicals such as BPA sometimes do not act in a typical way; they can have health effects at low doses but no effects or different effects at high doses.
The EPA frequently evaluates the safety of chemicals with tests that expose lab animals to high doses, then extrapolating to lower doses that people and wildlife encounter.
In a report last year, 12 scientists, including vom Saal, criticized that decades old-strategy, saying it fails to detect health threats from low doses of hormone-like chemicals. Pete Myers, founder of Environmental Health News and chief scientist at Environmental Health Sciences, was the senior author of that report.
Last month, reacting to that report, the EPA defended its testing, concluding that current testing of hormone-altering chemicals is adequate for detecting low-dose effects that may jeopardize health.
In response to vom Saal?s new study, a spokesperson for the American Chemistry Council, which represents chemical companies, said the findings had not been replicated and it ?presents conclusions that are not supported by the findings of EPA?s recent extensive review of the state of the science on low dose exposures.?
Source: http://rss.sciam.com/~r/ScientificAmerican-News/~3/o5ZuscGVs2I/article.cfm
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